HEK 293T cells were mock transfected (thin line) or transfected with an expression plasmid coding for the extracellular domain of human TNFRSF21 (thick line). Cells (5 X 105) were incubated on ice for 30 min in 50 uL FACS buffer (PBS, 5% FCS, 0.02% sodium azide) containing 1 ug/mL of TNFRSF21 monoclonal antibody, clone Luke-1 (Cat # MAB3436).
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB and MAPK8/JNK, and induce cell apoptosis. Through its death domain, this receptor interacts with TRADD protein, which is known to serve as an adaptor that mediates signal transduction of TNF-receptors. Knockout studies in mice suggested that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq
OTTHUMP00000016561,OTTHUMP00000039915,TNFR-related death receptor 6,death receptor 6