TNFRSF21 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TNFRSF21.
Immunogen
A synthetic peptide corresponding to amino acids 42-56 of human TNFRSF21.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of TNFRSF21 in K-562 (1, 3) and Raji (2, 4) whole cell lysate in the absence (1, 2) or presence (3, 4) of blocking peptide with TNFRSF21 polyclonal antibody (Cat # PAB12839) at 1 : 500 dilution. -
Gene Info — TNFRSF21
Entrez GeneID
27242Protein Accession#
AF068868Gene Name
TNFRSF21
Gene Alias
BM-018, DR6, MGC31965
Gene Description
tumor necrosis factor receptor superfamily, member 21
Omim ID
605732Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB and MAPK8/JNK, and induce cell apoptosis. Through its death domain, this receptor interacts with TRADD protein, which is known to serve as an adaptor that mediates signal transduction of TNF-receptors. Knockout studies in mice suggested that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq
Other Designations
OTTHUMP00000016561|OTTHUMP00000039915|TNFR-related death receptor 6|death receptor 6
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Interactome
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Pathway
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Disease
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Publication Reference
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Identification and functional characterization of DR6, a novel death domain-containing TNF receptor.
Pan G, Bauer JH, Haridas V, Wang S, Liu D, Yu G, Vincenz C, Aggarwal BB, Ni J, Dixit VM.
FEBS Letters 1998 Jul; 431(3):351.
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Identification and functional characterization of DR6, a novel death domain-containing TNF receptor.
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