ADRBK1 monoclonal antibody, clone 5D5 (Cat # MAB2373) (green) and neurofilament NF-M (red) staining, in rat cortex, showing mostly large pyramidal neurons. Photo courtesy of Dr. Gerry Shaw, University of Florida.
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq