ATIC monoclonal antibody, clone F38 P7 H9
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of ATIC.
Immunogen
A synthetic peptide corresponding to human ATIC.
Host
Mouse
Reactivity
Frog, Fruit fly, Human, Mouse, Rat
Form
Liquid
Isotype
IgG1
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of ATIC expression in HT-29 cell lysate in ATIC monoclonal antibody, clone F38 P7 H9 (Cat # MAB1824).Immunohistochemistry
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Gene Info — ATIC
Entrez GeneID
471Gene Name
ATIC
Gene Alias
AICAR, AICARFT, FLJ93545, IMPCHASE, PURH
Gene Description
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Gene Ontology
HyperlinkGene Summary
This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq
Other Designations
AICARFT/IMPCHASE
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Interactome
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Pathway
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Disease
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Publication Reference
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Mass spectrometric/bioinformatic identification of a protein subset that characterizes the cellular activity of anticancer peptides.
Genovese F, Gualandi A, Taddia L, Marverti G, Pirondi S, Marraccini C, Perco P, Pelà M, Guerrini R, Amoroso MR, Esposito F, Martello A, Ponterini G, D'Arca D, Costi MP.
The Journal of Proteome Research 2014 Nov; 13(11):5250.
Application:WB-Ce, Human, CSD-OC, A2780/CP, IGROV-1 cells.
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AICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATIC.
Marie S, Heron B, Bitoun P, Timmerman T, Van Den Berghe G, Vincent MF.
American Journal of Human Genetics 2004 Jun; 74(6):1276.
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The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling.
Bulock KG, Beardsley GP, Anderson KS.
The Journal of Biological Chemistry 2002 Jun; 277(25):22168.
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Mass spectrometric/bioinformatic identification of a protein subset that characterizes the cellular activity of anticancer peptides.
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