ATIC polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western Blot analysis of Jurkat cell lysate with ATIC polyclonal antibody (Cat # PAB29975) at 5 ug/mL working concentration.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with ATIC polyclonal antibody (Cat # PAB29975) at 4-8 ug/mL working concentration.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of human ATIC.
Immunogen
A synthetic peptide corresponding to internal region of human ATIC.
Sequence
RTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDLPESALRDLIVATIAVKYT
Host
Rabbit
Theoretical MW (kDa)
30
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (4-8 ug/mL)
Western Blot (5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (2% sucrose, 0.09% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of Jurkat cell lysate with ATIC polyclonal antibody (Cat # PAB29975) at 5 ug/mL working concentration.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with ATIC polyclonal antibody (Cat # PAB29975) at 4-8 ug/mL working concentration. -
Gene Info — ATIC
Entrez GeneID
471GeneBank Accession#
NM_004044Protein Accession#
EAW70527;P31939Gene Name
ATIC
Gene Alias
AICAR, AICARFT, FLJ93545, IMPCHASE, PURH
Gene Description
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Gene Ontology
HyperlinkGene Summary
This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq
Other Designations
AICARFT/IMPCHASE
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Interactome
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Pathway
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Disease
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