ERBB2 monoclonal antibody, clone A24-V
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of human ERBB2.
Immunogen
A synthetic peptide corresponding to C-terminus of human ERBB2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
EVAC purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:100-1:300)
The optimal working dilution should be determined by the end user.Storage Buffer
In 20 mM Tris-HCl buffer, pH 8.0 (20 mg/mL BSA, 0.05% Sodium Azide).
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human breast ductal carcinoma with ERBB2 monoclonal antibody, clone A24-V (Cat # MAB15956). -
Gene Info — ERBB2
Entrez GeneID
2064Protein Accession#
P04626Gene Name
ERBB2
Gene Alias
CD340, HER-2, HER-2/neu, HER2, NEU, NGL, TKR1
Gene Description
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq
Other Designations
c-erb B2/neu protein|erbB-2|herstatin|neuroblastoma/glioblastoma derived oncogene homolog|v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)
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Interactome
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Pathway
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Disease
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Publication Reference
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A comparative evaluation of the chelators H4octapa and CHX-A″-DTPA with the therapeutic radiometal (90)Y.
Price EW, Edwards KJ, Carnazza KE, Carlin SD, Zeglis BM, Adam MJ, Orvig C, Lewis JS.
Nuclear Medicine and Biology 2016 Sep; 43(9):566.
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Multicolor microRNA FISH effectively differentiates tumor types.
Renwick N, Cekan P, Masry PA, McGeary SE, Miller JB, Hafner M, Li Z, Mihailovic A, Morozov P, Brown M, Gogakos T, Mobin MB, Snorrason EL, Feilotter HE, Zhang X, Perlis CS, Wu H, Suarez-Farinas M, Feng H, Shuda M, Moore PS, Tron VA, Chang Y, Tuschl T.
The Journal of Clinical Investigation 2013 Jun; 123(6):2694.
Application:IHC-P, Human, Human breast cancer.
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A comparative evaluation of the chelators H4octapa and CHX-A″-DTPA with the therapeutic radiometal (90)Y.
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