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Cytokeratin monoclonal antibody, clone KRT/457

  • Catalog # : MAB14658
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native human Cytokeratin.
  • Immunogen:
  • Keratin-enriched preparation from cultured human epithelial cells.
  • Host:
  • Mouse
  • Reactivity:
  • Human, Rat
  • Specificity:
  • This antibody recognizes Type I and Type II cytokeratins, including CK4, CK5, CK6, CK8, CK10, CK13, and CK18.
  • Form:
  • Liquid
  • Purification:
  • Protein G purification
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Flow Cytometry (0.5-1 ug/million cells in 0.1 mL)
    Immunofluorescence (0.5-1 ug/mL)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
    Western Blot (0.5-1 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Storage Instruction:
  • In PBS.
  • Publication Reference
  • Applications
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of rat ovary with Cytokeratin monoclonal antibody, clone KRT/457 (Cat # MAB14658).
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human bladder carcinoma with Cytokeratin monoclonal antibody, clone KRT/457 (Cat # MAB14658).
  • Immunofluorescence
  • Flow Cytometry
  • Application Image
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Immunofluorescence
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 3851
  • Protein Accession#:
  • P02538; P04259; P13647; P19013; P48668; P05787; P13645; P13646; P05783
  • Gene Name:
  • KRT4
  • Gene Alias:
  • CK4,CYK4,FLJ31692,K4
  • Gene Description:
  • keratin 4
  • Gene Summary:
  • The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq
  • Other Designations:
  • cytokeratin 4,keratin, type II cytoskeletal 4
  • Gene Information
  • Entrez GeneID:
  • 3852
  • Protein Accession#:
  • P02538; P04259; P13647; P19013; P48668; P05787; P13645; P13646; P05783
  • Gene Name:
  • KRT5
  • Gene Alias:
  • CK5,DDD,EBS2,K5,KRT5A
  • Gene Description:
  • keratin 5
  • Gene Summary:
  • The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq
  • Other Designations:
  • 58 kda cytokeratin,epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types,keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types),keratin, type II cytoskeletal 5
  • Gene Information
  • Entrez GeneID:
  • 3853
  • Protein Accession#:
  • P02538; P04259; P13647; P19013; P48668; P05787; P13645; P13646; P05783
  • Gene Name:
  • KRT6A
  • Gene Alias:
  • CK6A,CK6C,CK6D,K6A,K6C,K6D,KRT6C,KRT6D
  • Gene Description:
  • keratin 6A
  • Gene Summary:
  • The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq
  • Other Designations:
  • 56 cytoskeletal type II keratin,K6D keratin,cytokeratin 6A,cytokeratin 6C,cytokeratin 6D,keratin 6C,keratin, epidermal type II, K6A,keratin, epidermal type II, K6C,keratin, type II cytoskeletal 6D,type II keratin isoform K6c
  • Gene Information
  • Entrez GeneID:
  • 3854
  • Protein Accession#:
  • P02538; P04259; P13647; P19013; P48668; P05787; P13645; P13646; P05783
  • Gene Name:
  • KRT6B
  • Gene Alias:
  • CK6B,K6B,KRTL1,PC2
  • Gene Description:
  • keratin 6B
  • Gene Summary:
  • The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq
  • Other Designations:
  • cytokeratin 6B,keratin, epidermal, type II, K6B,keratin, type II cytoskeletal 6B,keratin-like 1 (a type II keratin sequence)
  • Gene Information
  • Protein Accession#:
  • P02538; P04259; P13647; P19013; P48668; P05787; P13645; P13646; P05783
  • Gene Name:
  • KRT6C
  • Gene Alias:
  • K6E,KRT6E,MGC102925,MGC163455,MGC163457
  • Gene Description:
  • keratin 6C
  • Gene Summary:
  • Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq
  • Other Designations:
  • keratin 6E
  • Gene Information
  • Entrez GeneID:
  • 3856
  • Protein Accession#:
  • P02538; P04259; P13647; P19013; P48668; P05787; P13645; P13646; P05783
  • Gene Name:
  • KRT8
  • Gene Alias:
  • CARD2,CK8,CYK8,K2C8,K8,KO
  • Gene Description:
  • keratin 8
  • Gene Summary:
  • This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. [provided by RefSeq
  • Other Designations:
  • cytokeratin 8,keratin, type II cytoskeletal 8
  • Gene Information
  • Entrez GeneID:
  • 3858
  • Protein Accession#:
  • P02538; P04259; P13647; P19013; P48668; P05787; P13645; P13646; P05783
  • Gene Name:
  • KRT10
  • Gene Alias:
  • CK10,K10,KPP
  • Gene Description:
  • keratin 10
  • Gene Summary:
  • This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq
  • Other Designations:
  • cytokeratin 10
  • Gene Information
  • Entrez GeneID:
  • 3860
  • Protein Accession#:
  • P02538; P04259; P13647; P19013; P48668; P05787; P13645; P13646; P05783
  • Gene Name:
  • KRT13
  • Gene Alias:
  • CK13,K13,MGC161462,MGC3781
  • Gene Description:
  • keratin 13
  • Gene Summary:
  • The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq
  • Other Designations:
  • cytokeratin 13,keratin, type I cytoskeletal 13
  • Gene Information
  • Entrez GeneID:
  • 3875
  • Protein Accession#:
  • P02538; P04259; P13647; P19013; P48668; P05787; P13645; P13646; P05783
  • Gene Name:
  • KRT18
  • Gene Alias:
  • CYK18,K18
  • Gene Description:
  • keratin 18
  • Gene Summary:
  • KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
  • Other Designations:
  • cell proliferation-inducing protein 46,cytokeratin 18
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