Caldesmon monoclonal antibody, clone hHCD
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Specification
Product Description
Mouse monoclonal antibody raised against full length native human caldesmon.
Immunogen
Native purified caldesmon from human uterus smooth muscle.
Host
Mouse
Reactivity
Human, Mouse, Rabbit
Form
Liquid
Isotype
IgG1
Recommend Usage
Immunohistochemistry (2-4 ug/mL)
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In ascites (1.2% sodium acetate, 2 mg BSA, 0.01mg sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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Gene Info — CALD1
Entrez GeneID
800Protein Accession#
Q05682；Q8VCQ8；Q62736Gene Name
CALD1
Gene Alias
CDM, H-CAD, L-CAD, MGC21352, NAG22
Gene Description
caldesmon 1
Omim ID
114213Gene Ontology
HyperlinkGene Summary
This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq
Other Designations
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Interactome
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Pathway
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Disease
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Publication Reference
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Genomic structure of the human caldesmon gene.
Hayashi K, Yano H, Hashida T, Takeuchi R, Takeda O, Asada K, Takahashi E, Kato I, Sobue K.
PNAS 1992 Dec; 89(24):12122.
Application：WB-Ce, WB-Tr, Human, Mammalian cells.
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Cloning of cDNAs encoding human caldesmons.
Humphrey MB, Herrera-Sosa H, Gonzalez G, Lee R, Bryan J.
Gene 1992 Mar; 112(2):197.
Application：WB-Ce, WB-Tr, Human, Mammalian cells.
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Genomic structure of the human caldesmon gene.
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