Western blot analysis of Lane 1: human, Lane 2: mouse and Lane 3: rat full-length IL17A recombinant protein with IL17A monoclonal antibody, clone 4K5F6 (Cat # MAB12727) at 0.2 ug/mL working concentration.
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human small intestine with IL17A monoclonal antibody, clone 4K5F6 (Cat # MAB12727) at 5-10 ug/mL working concentration.
Flow cytometric analysis of human lymphocytes with IL17A monoclonal antibody, clone 4K5F6 (Cat # MAB12727) (red histogram) and an isotype control (green histogram) followed by FITC-conjugated goat anti-mouse IgG as the secondary antibody.
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq