Western blot analysis of Lane 1: Hela cell line lysates Lane 2: MCF-7 cell line lysates Lane 3: mouse C2C12 cell line lysates Lane 4: mouse NIH/3T3 cell line lysates Lane 5: rat C6 cell line lysates reacted with RPTOR monoclonal antibody (Cat # MAB12359) at 1:1000 dilution.
This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats,regulatory associated protein of mTOR