PDCD4 monoclonal antibody, clone k4C1
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of HepG2 cell lysates.
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant PDCD4.
Immunogen
Recombinant protein corresponding to full length human PDCD4.
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Isotype
IgG1, kappa
Recommend Usage
ELISA
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (10% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of HepG2 cell lysates.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PDCD4
Entrez GeneID
27250GeneBank Accession#
NM_014456Protein Accession#
NP_055271Gene Name
PDCD4
Gene Alias
H731, MGC33046, MGC33047
Gene Description
programmed cell death 4 (neoplastic transformation inhibitor)
Omim ID
608610Gene Ontology
HyperlinkGene Summary
This gene encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified. [provided by RefSeq
Other Designations
OTTHUMP00000020483|nuclear antigen H731|programmed cell death 4
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Interactome
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Disease
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Publication Reference
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Akt phosphorylates and regulates Pdcd4 tumor suppressor protein.
Palamarchuk A, Efanov A, Maximov V, Aqeilan RI, Croce CM, Pekarsky Y.
Cancer Research 2005 Dec; 65(24):11282.
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Novel human PDCD4 (H731) gene expressed in proliferative cells is expressed in the small duct epithelial cells of the breast as revealed by an anti-H731 antibody.
Yoshinaga H, Matsuhashi S, Fujiyama C, Masaki Z.
Pathology International 1999 Dec; 49(12):1067.
Application：IF, IHC-P, WB-Ce, Human, Bladder cancer, Breast cancer, HeLa, HT1376, MRC5, PC-3, U373, WiDr cells.
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Akt phosphorylates and regulates Pdcd4 tumor suppressor protein.
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