Western blot analysis using MAPK6 monoclonal antibody, clone 4E8 (Cat # MAB10801) against HEK293 (1) and MAPK6-hIgGFc transfected HEK293 (2) cell lysate.
The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq