MAP3K6 polyclonal antibody (A01)
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More Files
- More Functions
Western Blot detection against Immunogen (37.11 KDa) .
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Specification
Product Description
Mouse polyclonal antibody raised against a partial recombinant MAP3K6.
Immunogen
MAP3K6 (AAH15914, 225 a.a. ~ 325 a.a) partial recombinant protein with GST tag.
Sequence
HFWLHFLLQSCQPFKTACAQGDQCLVLVLEMNKVLLPAKLEVRGTDPVSTVTLSLLEPETQDIPSSWTFPVASICGVSASKRDERCCFLYALPPAQDVQLC
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (84); Rat (83)
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.11 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
ELISA
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Gene Info — MAP3K6
Entrez GeneID
9064GeneBank Accession#
BC015914Protein Accession#
AAH15914Gene Name
MAP3K6
Gene Alias
ASK2, MAPKKK6, MGC125653, MGC20114
Gene Description
mitogen-activated protein kinase kinase kinase 6
Omim ID
604468Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the serine/threonine protein kinase family. The encoded kinase was identified by its interaction with MAP3K5/ASK, a protein kinase and an activator of c-Jun kinase (MAPK7/JNK) and MAPK14/p38 kinase. This kinase was found to weakly activate MAPK7, but not MAPK1/ERK or MAPK14. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. [provided by RefSeq
Other Designations
OTTHUMP00000005063|apoptosis signal-regulating kinase 2
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Interactome
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Pathway
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Disease
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Publication Reference
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Dual engagement of 14-3-3 proteins controls signal relay from ASK2 to the ASK1 signalosome.
Cockrell LM, Puckett MC, Goldman EH, Khuri FR, Fu H.
Oncogene 2009 Nov; 29(6):822.
Application：WB, Human, COS-7, HeLa cells.
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Mitogen-Activated Protein 3 Kinase 6 Mediates Angiogenic and Tumorigenic Effects via Vascular Endothelial Growth Factor Expression.
Eto N, Miyagishi M, Inagi R, Fujita T, Nangaku M.
The American Journal of Pathology 2009 Apr; 174(4):1553.
Application：WB-Tr, Human, HeLa S3 cells.
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Dual engagement of 14-3-3 proteins controls signal relay from ASK2 to the ASK1 signalosome.
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