MAP3K6 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
The MAP3K6 polyclonal antibody (Cat # PAB2281) is used in Western blot to detect MAP3K6 in NIH/3T3 cell lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with the MAP3K6 polyclonal antibody (Cat # PAB2281) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MAP3K6.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human MAP3K6.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The MAP3K6 polyclonal antibody (Cat # PAB2281) is used in Western blot to detect MAP3K6 in NIH/3T3 cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with the MAP3K6 polyclonal antibody (Cat # PAB2281) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. -
Gene Info — MAP3K6
Entrez GeneID
9064Protein Accession#
O95382Gene Name
MAP3K6
Gene Alias
ASK2, MAPKKK6, MGC125653, MGC20114
Gene Description
mitogen-activated protein kinase kinase kinase 6
Omim ID
604468Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the serine/threonine protein kinase family. The encoded kinase was identified by its interaction with MAP3K5/ASK, a protein kinase and an activator of c-Jun kinase (MAPK7/JNK) and MAPK14/p38 kinase. This kinase was found to weakly activate MAPK7, but not MAPK1/ERK or MAPK14. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. [provided by RefSeq
Other Designations
OTTHUMP00000005063|apoptosis signal-regulating kinase 2
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Interactome
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Pathway
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Disease
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Publication Reference
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MAPKKK6, a novel mitogen-activated protein kinase kinase kinase, that associates with MAPKKK5.
Wang XS, Diener K, Tan TH, Yao Z.
Biochemical and Biophysical Research Communications 1998 Dec; 253(1):33.
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MAPKKK6, a novel mitogen-activated protein kinase kinase kinase, that associates with MAPKKK5.
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