PTGDS polyclonal antibody (A01)
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More Files
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Specifications
Product Description
Mouse polyclonal antibody raised against a full-length recombinant PTGDS.
Immunogen
PTGDS (AAH05939, 1 a.a. ~ 190 a.a) full-length recombinant protein with GST tag.
Sequence
MATHHTLWMGLALLGVLGDLQAAPEAQVSVQPNFQQDKFLGRWFSAGLASNSSWLREKKAALSMCKSVVAPATDGGLNLTSTFLRKNQCETRTMLLQPAGSLGSYSYRSPHWGSTYSVSVVETDYDQYALLYSQGSKGPGEDFRMATLYSRTQTPRAELKEKFTAFCKAQGFTEDTIVFLPQTDKCMTEQ
Host
Mouse
Reactivity
Human
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (47.01 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
ELISA
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Gene Info — PTGDS
Entrez GeneID
5730GeneBank Accession#
BC005939Protein Accession#
AAH05939Gene Name
PTGDS
Gene Alias
LPGDS, PDS, PGD2, PGDS, PGDS2
Gene Description
prostaglandin D2 synthase 21kDa (brain)
Omim ID
176803Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq
Other Designations
OTTHUMP00000022638|PGD2 synthase|beta-trace protein|glutathione-independent PGD synthase|lipocalin-type prostaglandin D synthase|prostaglandin D synthase|prostaglandin D2 synthase (21kD, brain)|prostaglandin H2 D-isomerase|prostaglandin-H2 D-isomerase
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Decreased intrathecal synthesis of prostaglandin D(2) synthase in the cerebrospinal fluid of patients with acute inflammatory demyelinating polyneuropathy.
Huang YC, Lyu RK, Tseng MY, Chang HS, Hsu WC, Kuo HC, Chu CC, Wu YR, Ro LS, Huang CC, Chen CM.
Journal of Neuroimmunology 2008 Dec; 206(1-2):100.
Application:WB, Human, Cerebrospinal fluid from patients with acute inflammatory demyelinating polyneuropathy , Miller-Fisher syndrome , chronic inflammatorydemyelinating polyradiculoneuropathy, and multiple sclerosis .
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7beta-Hydroxy-epiandrosterone-mediated regulation of the prostaglandin synthesis pathway in human peripheral blood monocytes.
Mee SL, Hennebert O, Ferrec C, Wulfert E, Morfin R.
Steroids 2008 May; 73(11):1148.
Application:WB-Ce, Human, PBMCs.
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Decreased intrathecal synthesis of prostaglandin D(2) synthase in the cerebrospinal fluid of patients with acute inflammatory demyelinating polyneuropathy.
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