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Last updated: 2016/10/16
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KPNA2 polyclonal antibody (A01)

  • Catalog # : H00003838-A01
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  • Specification
  • Product Description:
  • Mouse polyclonal antibody raised against a partial recombinant KPNA2.
  • Immunogen:
  • KPNA2 (NP_002257, 420 a.a. ~ 528 a.a) partial recombinant protein with GST tag.
  • Sequence:
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Quality Control Testing:
  • Antibody Reactive Against Recombinant Protein.

    QC Testing of H00003838-A01
    Western Blot detection against Immunogen (38.1 KDa) .
  • Storage Buffer:
  • 50 % glycerol
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Application Image
  • Western Blot (Recombinant protein)
  • Gene Information
  • Entrez GeneID:
  • 3838
  • Gene Name:
  • KPNA2
  • Gene Alias:
  • IPOA1,QIP2,RCH1,SRP1alpha
  • Gene Description:
  • karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
  • Gene Summary:
  • The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq
  • Other Designations:
  • RAG cohort 1,importin alpha 1,importin alpha 2,importin-alpha-P1,karyopherin alpha 2,pendulin
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