KPNA2 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of KPNA2 in rat heart tissue lysate with KPNA2 polyclonal antibody (Cat # PAB19315) at (1) 1 and (2) 2 ug/mL.
Immunohistochemistry
Immunohistochemical staining of human heart cells with KPNA2 polyclonal antibody (Cat # PAB19315) at 5 ug/mL.
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Specification
Product Description
Rabbit polyclonal antibody rasied against synthetic peptide of KPNA2.
Immunogen
A synthetic peptide corresponding to 15 amino acids near N-terminus of human KPNA2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Peptide affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1-2 ug/mL)
Immunohistochemistry (5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of KPNA2 in rat heart tissue lysate with KPNA2 polyclonal antibody (Cat # PAB19315) at (1) 1 and (2) 2 ug/mL.Immunohistochemistry
Immunohistochemical staining of human heart cells with KPNA2 polyclonal antibody (Cat # PAB19315) at 5 ug/mL.Enzyme-linked Immunoabsorbent Assay
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Gene Info — KPNA2
Entrez GeneID
3838Protein Accession#
NP_002257Gene Name
KPNA2
Gene Alias
IPOA1, QIP2, RCH1, SRP1alpha
Gene Description
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
Omim ID
600685Gene Ontology
HyperlinkGene Summary
The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq
Other Designations
RAG cohort 1|importin alpha 1|importin alpha 2|importin-alpha-P1|karyopherin alpha 2|pendulin
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Interactome
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Disease
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