XRCC5 polyclonal antibody
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Specifications
Product Description
Goat polyclonal antibody raised against synthetic peptide of XRCC5.
Immunogen
A synthetic peptide corresponding to human XRCC5.
Sequence
C-SLAKKDEKTDTLED
Host
Goat
Theoretical MW (kDa)
82.7
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:16000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
XRCC5 polyclonal antibody (Cat # PAB7008) (0.1 ug/mL) staining of HeLa cell lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — XRCC5
Entrez GeneID
7520Protein Accession#
NP_066964.1Gene Name
XRCC5
Gene Alias
FLJ39089, KARP-1, KARP1, KU80, KUB2, Ku86, NFIV
Gene Description
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
Omim ID
194364Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq
Other Designations
ATP-dependent DNA helicase II|DNA repair protein XRCC5|Ku autoantigen, 80kDa|Ku86 autoantigen related protein 1|X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kD)|X-ray repair, comp
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Ku is a novel transcriptional recycling coactivator of the androgen receptor in prostate cancer cells.
Mayeur GL, Kung WJ, Martinez A, Izumiya C, Chen DJ, Kung HJ.
The Journal of Biological Chemistry 2005 Mar; 280(11):10827.
Application:IP, WB-Tr, Human, Insect, Sf9, PC-3 cells.
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Ku is a novel transcriptional recycling coactivator of the androgen receptor in prostate cancer cells.
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