CSNK2A1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
The CSNK2A1 polyclonal antibody (Cat # PAB4015) is used in Western blot to detect CSNK2A1 in mouse brain tissue lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human breast cancer tissue reacted with CSNK2A1 polyclonal antibody (Cat # PAB4015) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CSNK2A1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to internal region of human CSNK2A1.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The CSNK2A1 polyclonal antibody (Cat # PAB4015) is used in Western blot to detect CSNK2A1 in mouse brain tissue lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human breast cancer tissue reacted with CSNK2A1 polyclonal antibody (Cat # PAB4015) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CSNK2A1
Entrez GeneID
1457Protein Accession#
P19138Gene Name
CSNK2A1
Gene Alias
CK2A1, CKII
Gene Description
casein kinase 2, alpha 1 polypeptide
Omim ID
115440Gene Ontology
HyperlinkGene Summary
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq
Other Designations
CK2 catalytic subunit alpha|OTTHUMP00000029925|OTTHUMP00000029926|casein kinase II alpha 1 subunit|casein kinase II alpha subunit|protein kinase CK2
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Interactome
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Pathway
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Disease
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Publication Reference
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CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37.
Miyata Y, Nishida E.
Molecular and Cellular Biology 2004 May; 24(9):4065.
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Protein kinase CK2: a new view of an old molecular complex.
Filhol O, Martiel JL, Cochet C.
EMBO Reports 2004 Apr; 5(4):351.
Application：IHC, WB, Human, Cancers, Mammalian cells.
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The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks.
Loizou JI, El-Khamisy SF, Zlatanou A, Moore DJ, Chan DW, Qin J, Sarno S, Meggio F, Pinna LA, Caldecott KW.
Cell 2004 Apr; 117(1):17.
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CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37.
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