XRCC5 monoclonal antibody, clone 6
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant XRCC5.
Immunogen
Recombinant protein corresponding to amino acids 1-210 of human XRCC5.
Host
Mouse
Reactivity
Human
Specificity
It can expression in SW480 whole cell lysate.
Form
Liquid
Purification
Affinity purification
Isotype
IgG2a
Recommend Usage
Western blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Citrate-Tris-HCl buffer, pH 7.0 (0.02% Proclin 300)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Cell lysate)
Western blot analysis of SW480 whole cell lystae with XRCC5 monoclonal antibody, clone 6 (Cat # MAB9925) at 1:1000 dilution.Enzyme-linked Immunoabsorbent Assay
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Gene Info — XRCC5
Entrez GeneID
7520GeneBank Accession#
NM_021141Protein Accession#
NP_066964Gene Name
XRCC5
Gene Alias
FLJ39089, KARP-1, KARP1, KU80, KUB2, Ku86, NFIV
Gene Description
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
Omim ID
194364Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq
Other Designations
ATP-dependent DNA helicase II|DNA repair protein XRCC5|Ku autoantigen, 80kDa|Ku86 autoantigen related protein 1|X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kD)|X-ray repair, comp
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Interactome
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Pathway
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Disease
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