RAD17 purified MaxPab rabbit polyclonal antibody (D01P)
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human RAD17 protein.
Immunogen
RAD17 (NP_579919.1, 1 a.a. ~ 584 a.a) full-length human protein.
Sequence
MNQHELAVHKKKIEEVETWLKAQVLERQPKQGGSILLITGPPGCGKTTTLKILSKEHGIQVQEWINPVLPDFQKDDFKGMFNTESSFHMFPYQSQIAVFKEFLLRATKYNKLQMLGDDLRTDKKIILVEDLPNQFYRDSHTLHEVLRKYVRIGRCPLIFIISDSLSGDNNQRLLFPKEIQEECSISNISFNPVAPTIMMKFLNRIVTIEANKNGGKITVPDKTSLELLCQGCSGDIRSAINSLQFSSSKGENNLRPRKKGMSLKSDAVLSKSKRRKKPDRVFENQEVQAIGGKDVSLFLFRALGKILYCKRASLTELDSPRLPSHLSEYERDTLLVEPEEVVEMSHMPGDLFNLYLHQNYIDFFMEIDDIVRASEFLSFADILSGDWNTRSLLREYSTSIATRGVMHSNKARGYAHCQGGGSSFRPLHKPQWFLINKKYRENCLAAKALFPDFCLPALCLQTQLLPYLALLTIPMRNQAQISFIQDIGRLPLKRHFGRLKMEALTDREHGMIDPDSGDEAQLNGGHSAEESLGEPTQATVPETWSLPLSQNSASELPASQPQPFSAQGDMEENIIIEDYESDGT
Host
Rabbit
Reactivity
Human, Mouse
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
RAD17 MaxPab rabbit polyclonal antibody. Western Blot analysis of RAD17 expression in human kidney.Western Blot (Tissue lysate)
RAD17 MaxPab rabbit polyclonal antibody. Western Blot analysis of RAD17 expression in mouse lung.Western Blot (Cell lysate)
RAD17 MaxPab rabbit polyclonal antibody. Western Blot analysis of RAD17 expression in Hela S3 NE.Western Blot (Transfected lysate)
Western Blot analysis of RAD17 expression in transfected 293T cell line (H00005884-T02) by RAD17 MaxPab polyclonal antibody.
Lane 1: RAD17 transfected lysate(66.20 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — RAD17
Entrez GeneID
5884GeneBank Accession#
NM_133341Protein Accession#
NP_579919.1Gene Name
RAD17
Gene Alias
CCYC, FLJ41520, HRAD17, R24L, RAD17SP, RAD24
Gene Description
RAD17 homolog (S. pombe)
Omim ID
603139Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq
Other Designations
OTTHUMP00000125189|OTTHUMP00000125190|OTTHUMP00000125192|OTTHUMP00000125193|OTTHUMP00000125194|RAD1 homolog|RAD17 homolog|RF-C activator 1 homolog|Rad17-like protein|cell cycle checkpoint protein (RAD17)
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Interactome
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Disease
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