SLC6A4 recombinant monoclonal antibody, clone 9G3
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human SLC6A4.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to human SLC6A4.
Theoretical MW (kDa)
Calculated MW: 71,75
Reactivity
Human
Form
Liquid
Purification
Affinity chromatography purification
Isotype
IgG
Recommend Usage
ELISA
Immunohistochemistry (1:50-1:200)
Western Blot (1:500-1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.4 (150 mM NaCl, 0.02% sodium azide and 50% glycerol)
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of 293Twhole cell lysate, U251 whole cell lysate , HepG2 whole cell lysate with SLC6A4 recombinant monoclonal antibody, clone 9G3 (Cat # RAB07404).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human testis tissue using SLC6A4 recombinant monoclonal antibody, clone 9G3 (Cat # RAB07404) on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.Enzyme-linked Immunoabsorbent Assay
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Gene Info — SLC6A4
Entrez GeneID
6532Protein Accession#
P31645Gene Name
SLC6A4
Gene Alias
5-HTT, 5HTT, HTT, OCD1, SERT, hSERT
Gene Description
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Gene Ontology
HyperlinkGene Summary
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq
Other Designations
5-hydroxytryptamine transporter|5HT transporter|Na+/Cl- dependent serotonin transporter|serotonin transporter|sodium-dependent serotonin transporter|solute carrier family 6 member 4
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Interactome
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Disease
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