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Western Blot

Immunofluorescence

Immunofluorescent staining of HepG2 cells with TNFRSF10B recombinant monoclonal antibody, clone TRA-8 (Cat # RAB03416).
Immunofluorescence analysis of paraformaldehyde fixed HepG2 cells stained with the chimeric r version of RAB03416 at 10 ug/mL for 1h followed by Alexa Fluor® 488 secondary antibody (2 ug/mL), showing cytoplasmic staining. The nuclear stain is DAPI (blue). The isotype control was stained with anti-Fluorescein antibody followed by staining with Alexa Fluor® 488 secondary antibody.
(A) RAB03416
(B) DAPI
(C) Merged channels
(D) Isotype control

Enzyme-linked Immunoabsorbent Assay

Flow Cytometry

Entrez GeneID

8795

Gene Name

TNFRSF10B

Gene Alias

CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9

Gene Description

tumor necrosis factor receptor superfamily, member 10b

Omim ID

275355 603612

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq

Other Designations

Fas-like protein|OTTHUMP00000123492|TNF-related apoptosis-inducing ligand receptor 2|TRAIL receptor 2|apoptosis inducing protein TRICK2A/2B|apoptosis inducing receptor TRAIL-R2|cytotoxic TRAIL receptor-2|death domain containing receptor for TRAIL/Apo-2L|d