CRKL recombinant monoclonal antibody, clone CrkLY207-G4 (APC)
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More Files
- More Functions
Flow Cytometry
Flow cytometric analysis of K562 cells treated with imatinib and unstained (blue) as negative control or treated with imatinib (red) or treated with pervanadate (green) and stained using Phospho-CrkL (Tyr207) APC conjugated antibody CrkLY207-G4.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human CRKL.
Antibody Species
Rabbit
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Tyr207 of human phospho CrkL
Reactivity
Human
Form
Liquid
Conjugation
APC
Purification
Protein A purification, Protein G purification
Isotype
IgG
Recommend Usage
Flow Cytometry
The optimal working dilution should be determined by the end user.Storage Buffer
1X PBS, 0.09% Sodium azide, 0.2% BSA
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of K562 cells treated with imatinib and unstained (blue) as negative control or treated with imatinib (red) or treated with pervanadate (green) and stained using Phospho-CrkL (Tyr207) APC conjugated antibody CrkLY207-G4. -
Gene Info — CRKL
Entrez GeneID
1399Protein Accession#
P46109Gene Name
CRKL
Gene Alias
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Gene Description
v-crk sarcoma virus CT10 oncogene homolog (avian)-like
Omim ID
602007Gene Ontology
HyperlinkGene Summary
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic
Other Designations
v-crk avian sarcoma virus CT10 oncogene homolog-like
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Interactome
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Pathway
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Disease
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