ARNT recombinant monoclonal antibody, clone R05-3B2

Catalog # RAB01436

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Price

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Quantity

Size:100 uL
Price: USD $ 428.00
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Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
Images
Western Blot
Application

Western Blot

Western blot analysis of HIF1 beta in Hela, CHO-K1, C6, Ramos lysates using HIF1 beta antibody.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Application

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemistry analysis of paraffin-embedded Human lung cancer using HIF1 beta antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

  • Specification

    Product Description

    Rabbit recombinant monoclonal antibody raised against human ARNT.Recombinant Antibody,Recombinant Antibodies,Recombinant Monoclonal Antibody,RecomAb,Recombinant Ab,Recombinant Monoclonal Antibodies,Recombinant Abs

    Antibody Species

    Rabbit

    Immunogen

    Original antibody is raised against recombinant protein corresponding to human ARNT.

    Theoretical MW (kDa)

    Calculated MW: 87 kD

    Reactivity

    Human

    Form

    Liquid

    Purification

    Affinity purification

    Isotype

    IgG

    Recommend Usage

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Western Blot
    The optimal working dilution should be determined by the end user.

    Storage Buffer

    In 50mM Tris-Glycine, pH 7.4, (0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA)

    Storage Instruction

    Store at 4°C. For longer storage, aliquot and store at -20°C.
    Aliquot to avoid repeated freezing and thawing.

    Note

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

  • Applications

    Western Blot

    Western blot analysis of HIF1 beta in Hela, CHO-K1, C6, Ramos lysates using HIF1 beta antibody.

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

    Immunohistochemistry analysis of paraffin-embedded Human lung cancer using HIF1 beta antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
  • Gene Info — ARNT

    Entrez GeneID

    405

    Protein Accession#

    P27540

    Gene Name

    ARNT

    Gene Alias

    HIF-1beta, HIF1B, HIF1BETA, TANGO, bHLHe2

    Gene Description

    aryl hydrocarbon receptor nuclear translocator

    Omim ID

    126110

    Gene Ontology

    Hyperlink

    Gene Summary

    The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Three alternatively spliced variants encoding different isoforms have been described for this gene. [provided by RefSeq

    Other Designations

    OTTHUMP00000032943|dioxin receptor, nuclear translocator|hypoxia-inducible factor 1, beta subunit

  • Interactome
  • Pathway
  • Disease
Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
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