UBE3A recombinant monoclonal antibody, clone R02-1A0
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human UBE3A.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to human UBE3A.
Theoretical MW (kDa)
Calculated MW: 101 k
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunocytochemistry
Immunofluorescence
Immunoprecipitation
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In 50mM Tris-Glycine, pH 7.4, (0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at 4°C. For longer storage, aliquot and store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunocytochemistry
Immunocytochemistry analysis of Ubiquitin Protein Ligase E3A (green) in Hela using Ubiquitin Protein Ligase E3A antibody,and DAPI(blue).Immunofluorescence
Immunoprecipitation
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Gene Info — UBE3A
Entrez GeneID
7337Protein Accession#
Q05086Gene Name
UBE3A
Gene Alias
ANCR, AS, E6-AP, EPVE6AP, FLJ26981, HPVE6A
Gene Description
ubiquitin protein ligase E3A
Gene Ontology
HyperlinkGene Summary
This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq
Other Designations
CTCL tumor antigen se37-2|human papilloma virus E6-associated protein|oncogenic protein-associated protein E6-AP
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Interactome
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Pathway
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Disease
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