CD40LG recombinant monoclonal antibody, clone IDEC-131 (Toralizumab)
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More Files
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Immunofluorescence
Immunofluorescence analysis of paraformaldehyde fixed Jurkat cells on coverslips stained with the chimeric rabbit IgG version of IDEC-131 (Toralizumab) at 10 ug/mL for 1h followed by Alexa Fluor 488 secondary antibody (2 ug/mL), showing membrane staining. The nuclear stain is DAPI (blue). Panels show from left-right, top-bottom, DAPI, merged channels and an isotype control. The isotype control was an unknown specificity antibody followed by staining with Alexa Fluor 488 secondary antibody.
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Specification
Product Description
Mouse recombinant monoclonal antibody raised against human CD154.
Antibody Species
Mouse
Immunogen
Original antibody is raised against by immunization with a soluble fusion protein of human gp39.
Reactivity
Human
Specificity
This antibody is a non agonistic antibody specifc for human CD40 ligand.
Form
Liquid
Purification
Protein A affinity purification
Isotype
IgG1, Kappa
Recommend Usage
Immunofluorescence
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS with 0.02% Proclin 300
Storage Instruction
Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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Applications
Immunofluorescence
Immunofluorescence analysis of paraformaldehyde fixed Jurkat cells on coverslips stained with the chimeric rabbit IgG version of IDEC-131 (Toralizumab) at 10 ug/mL for 1h followed by Alexa Fluor 488 secondary antibody (2 ug/mL), showing membrane staining. The nuclear stain is DAPI (blue). Panels show from left-right, top-bottom, DAPI, merged channels and an isotype control. The isotype control was an unknown specificity antibody followed by staining with Alexa Fluor 488 secondary antibody. -
Gene Info — CD40LG
Entrez GeneID
959Protein Accession#
P29965Gene Name
CD40LG
Gene Alias
CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L
Gene Description
CD40 ligand
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq
Other Designations
CD40 antigen ligand|OTTHUMP00000024130|T-B cell-activating molecule|TNF-related activation protein|tumor necrosis factor (ligand) superfamily member 5
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Interactome
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Disease
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