CD8A recombinant monoclonal antibody, clone C8/1779R
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human CD8A.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to full length human CD8A.
Theoretical MW (kDa)
32
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Isotype
IgG, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (2-4 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS (0.05% BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human lymphoma with CD8A recombinant monoclonal antibody, clone C8/1779R (Cat # RAB00363).Immunofluorescence
Flow Cytometry
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Gene Info — CD8A
Entrez GeneID
925Protein Accession#
P01732Gene Name
CD8A
Gene Alias
CD8, Leu2, MAL, p32
Gene Description
CD8a molecule
Gene Ontology
HyperlinkGene Summary
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a corepressor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains, or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
CD8 antigen alpha polypeptide|CD8 antigen, alpha polypeptide (p32)|Leu2 T-lymphocyte antigen|OKT8 T-cell antigen|T cell co-receptor|T-cell antigen Leu2|T-cell surface glycoprotein CD8 alpha chain|T-lymphocyte differentiation antigen T8/Leu-2|T8 T-cell ant
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Interactome
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Pathway
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Publication Reference
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Immunohistological detection of human cytotoxic/suppressor T cells using antibodies to a CD8 peptide sequence.
Mason DY, Cordell JL, Gaulard P, Tse AG, Brown MH.
Journal of Clinical Pathology 1992 Dec; 45(12):1084.
Application:IHC-Fr, IHC-P, IP, Human, B cell lymphomas, Human T lymphoblasts.
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Immunohistological detection of human cytotoxic/suppressor T cells using antibodies to a CD8 peptide sequence.
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