TSPO polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
TSPO polyclonal antibody (Cat # PAB7095) (0.1 ug/mL) staining of human brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
TSPO polyclonal antibody (Cat # PAB7095) (2.5 ug/mL) staining of paraffin embedded human colon. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of TSPO.
Immunogen
A synthetic peptide corresponding to human TSPO.
Sequence
C-RDNHGWRGGRRLPE
Host
Goat
Theoretical MW (kDa)
18.8
Reactivity
Human
Specificity
This antibody is expected to recognize one isoform (NP_000705.2) only.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:128000)
Western Blot (0.1-0.3 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
TSPO polyclonal antibody (Cat # PAB7095) (0.1 ug/mL) staining of human brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
TSPO polyclonal antibody (Cat # PAB7095) (2.5 ug/mL) staining of paraffin embedded human colon. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — TSPO
Entrez GeneID
706Protein Accession#
NP_000705.2Gene Name
TSPO
Gene Alias
BZRP, DBI, IBP, MBR, PBR, PKBS, PTBR, mDRC, pk18
Gene Description
translocator protein (18kDa)
Omim ID
109610Gene Ontology
HyperlinkGene Summary
Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Other Designations
OTTHUMP00000028891|benzodiazepine peripheral binding site|mitochondrial benzodiazepine receptor|peripheral benzodiazepine receptor|peripheral-type benzodiazepine receptor|translocator protein
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Interactome
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Pathway
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Disease
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Publication Reference
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Kinetic modelling of [11C]PBR28 for 18 kDa translocator protein PET data: A validation study of vascular modelling in the brain using XBD173 and tissue analysis.
Veronese M, Reis Marques T, Bloomfield PS, Rizzo G, Singh N, Jones D, Agushi E, Mosses D, Bertoldo A, Howes O, Roncaroli F, Turkheimer FE.
Journal of Cerebral Blood Flow and Metabolism 2017 Jan; 271678X17712388.
Application：IF, IHC-P, Human, Human brain.
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Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function.
Papadopoulos V, Baraldi M, Guilarte TR, Knudsen TB, Lacapere JJ, Lindemann P, Norenberg MD, Nutt D, Weizman A, Zhang MR, Gavish M.
Trends in Pharmacological Sciences 2006 Aug; 27(8):402.
Application：IF, WB, Human, Human mammalian cells.
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Kinetic modelling of [11C]PBR28 for 18 kDa translocator protein PET data: A validation study of vascular modelling in the brain using XBD173 and tissue analysis.
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