LEPR polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of LEPR.
Immunogen
A synthetic peptide corresponding to human LEPR.
Sequence
C-TQDDIEKHQSDAG
Host
Goat
Theoretical MW (kDa)
132, 102, 109
Reactivity
Human
Specificity
This antibody is expected to recognize all three reported isoforms (NP_002294.2, NP_0010.03679.1, NP_0010.03680.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:16000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
LEPR polyclonal antibody (Cat # PAB7037) (1 ug/mL) staining of human brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — LEPR
Entrez GeneID
3953Protein Accession#
NP_002294.2;NP_0010.03679.1;NP_0010.03680.1Gene Name
LEPR
Gene Alias
CD295, OBR
Gene Description
leptin receptor
Omim ID
601007Gene Ontology
HyperlinkGene Summary
Leptin (LEP; MIM 164160), an adipocyte-specific hormone that regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure, acts through the leptin receptor (LEPR), a single-transmembrane-domain receptor of the cytokine receptor family.[supplied by OMIM
Other Designations
OB receptor|OTTHUMP00000010693|OTTHUMP00000010694
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Interactome
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Pathway
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Disease
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Publication Reference
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Leptin and leptin receptor polymorphisms are associated with increased risk and poor prognosis of breast carcinoma.
Snoussi K, Strosberg AD, Bouaouina N, Ben Ahmed S, Helal AN, Chouchane L.
BMC Cancer 2006 Feb; 6:38.
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Leptin and leptin receptor polymorphisms are associated with increased risk and poor prognosis of breast carcinoma.
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