NTRK1 (phospho Y701) polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
Western blot analysis of Lane 1: Untreated mouse brain cell lysates, Lane 2: Synthesized peptide treated mouse brain cell lysates reacted with NTRK1 (phospho Y701) polyclonal antibody (Cat # PAB29637) at 1:500-1:3000 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of paraffin-embedded human brain tissue reacted with NTRK1 (phospho Y701) polyclonal antibody (Cat # PAB29637) at 1:50-1:100 dilution. The picture on the right is treated with the synthesized peptide.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of human NTRK1.
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y701 of human NTRK1.
Host
Rabbit
Theoretical MW (kDa)
87
Reactivity
Human, Mouse, Rat
Specificity
NTRK1 (phospho Y701) polyclonal antibody detects endogenous levels of human NTRK1 only when phosphorylated at tyrosine 701.
Form
Liquid
Purification
Affinity chromatography
Recommend Usage
Immunohistochemistry (1:50-1:100)
Western Blot (1:500-1:3000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of Lane 1: Untreated mouse brain cell lysates, Lane 2: Synthesized peptide treated mouse brain cell lysates reacted with NTRK1 (phospho Y701) polyclonal antibody (Cat # PAB29637) at 1:500-1:3000 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of paraffin-embedded human brain tissue reacted with NTRK1 (phospho Y701) polyclonal antibody (Cat # PAB29637) at 1:50-1:100 dilution. The picture on the right is treated with the synthesized peptide. -
Gene Info — NTRK1
Entrez GeneID
4914Protein Accession#
P04629Gene Name
NTRK1
Gene Alias
DKFZp781I14186, MTC, TRK, TRK1, TRKA, p140-TrkA
Gene Description
neurotrophic tyrosine kinase, receptor, type 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq
Other Designations
OTTHUMP00000038736|Oncogene TRK|high affinity nerve growth factor receptor|tyrosine kinase receptor A
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Interactome
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Pathway
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Disease
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