CLEC7A polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of rat spleen tissue lysate with CLEC7A polyclonal antibody (Cat # PAB25491) at (1) 1 and (2) 2 ug/mL.
Immunohistochemistry
Immunohistochemical anyalysis of human spleen tissue with CLEC7A polyclonal antibody (Cat # PAB25491) at 5 ug/mL.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CLEC7A.
Immunogen
A synthetic peptide corresponding to internal region of human CLEC7A.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
Multiple isoforms of CLEC7A are known to exist.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1-2 ug/mL)
Immunohistochemistry (5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of rat spleen tissue lysate with CLEC7A polyclonal antibody (Cat # PAB25491) at (1) 1 and (2) 2 ug/mL.Immunohistochemistry
Immunohistochemical anyalysis of human spleen tissue with CLEC7A polyclonal antibody (Cat # PAB25491) at 5 ug/mL.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CLEC7A
Entrez GeneID
64581Protein Accession#
NP_922938Gene Name
CLEC7A
Gene Alias
BGR, CLECSF12, DECTIN1
Gene Description
C-type lectin domain family 7, member A
Omim ID
606264Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq
Other Designations
C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12|beta-glucan receptor|dectin-1|dendritic cell-associated C-type lectin 1|dendritic cell-associated C-type lectin-1|lectin-like receptor 1
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Interactome
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Disease
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Publication Reference
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Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.
Teresa W-M Fan, Saeed Daneshmandi, Teresa A Cassel, Mohammad B Uddin, James Sledziona, Patrick T Thompson, Penghui Lin, Richard M Higashi, Andrew N Lane.
Journal of immunology 2022 Nov; 209(9):1674.
Application：Array, Human, Human monocytes.
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Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.
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