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Entrez GeneID

Protein Accession#

Gene Name

STK3

Gene Alias

FLJ90748, KRS1, MST2

Gene Description

serine/threonine kinase 3 (STE20 homolog, yeast)

Omim ID

Gene Ontology

Gene Summary

Protein kinase activation is a frequent response of cells to treatment with growth factors, chemicals, heat shock, or apoptosis-inducing agents. This protein kinase activation presumably allows cells to resist unfavorable environmental conditions. The yeast 'sterile 20' (Ste20) kinase acts upstream of the mitogen-activated protein kinase (MAPK) cascade that is activated under a variety of stress conditions. MST2 was identified as a kinase that is activated by the proapoptotic agents straurosporine and FAS ligand (MIM 134638) (Taylor et al., 1996 [PubMed 8816758]; Lee et al., 2001 [PubMed 11278283]).[supplied by OMIM

Other Designations

serine/threonine kinase 3 (Ste20, yeast homolog)

Entrez GeneID

Protein Accession#

Gene Name

STK4

Gene Alias

DKFZp686A2068, KRS2, MST1, YSK3

Gene Description

serine/threonine kinase 4

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq

Other Designations

OTTHUMP00000043418|dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2))|kinase responsive to stress 2|mammalian sterile 20-like 1|yeast Ste20-like