TBK1 polyclonal antibody
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Immunocytochemistry
Immunocytochemistry of TBK1 in MOLT 4 cells with TBK1 polyclonal antibody (Cat # PAB12859) at 10 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TBK1.
Immunogen
A synthetic peptide corresponding to C-terminus 17 amino acids of human TBK1.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
A 84 KDa band should be detected. It is human, mouse and rat reactive and has no cross response to IKKa, IKKb, IKKy, or IKKe.
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunocytochemistry
Immunocytochemistry of TBK1 in MOLT 4 cells with TBK1 polyclonal antibody (Cat # PAB12859) at 10 ug/mL . -
Gene Info — TBK1
Entrez GeneID
29110Protein Accession#
NP_037386Gene Name
TBK1
Gene Alias
FLJ11330, NAK, T2K
Gene Description
TANK-binding kinase 1
Omim ID
604834Gene Ontology
HyperlinkGene Summary
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK. [provided by RefSeq
Other Designations
NF-kB-activating kinase
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Interactome
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Pathway
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Disease
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Publication Reference
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Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription.
Bonnard M, Mirtsos C, Suzuki S, Graham K, Huang J, Ng M, Itie A, Wakeham A, Shahinian A, Henzel WJ, Elia AJ, Shillinglaw W, Mak TW, Cao Z, Yeh WC.
The EMBO Journal 2000 Sep; 19(18):4976.
Application：WB-Ce, Human, 293 cells.
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NAK is an IkappaB kinase-activating kinase.
Tojima Y, Fujimoto A, Delhase M, Chen Y, Hatakeyama S, Nakayama K, Kaneko Y, Nimura Y, Motoyama N, Ikeda K, Karin M, Nakanishi M.
Nature 2000 Apr; 404(6779):778.
Application：IP, WB, Human, HeLa cells.
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NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase.
Pomerantz JL, Baltimore D.
The EMBO Journal 1999 Dec; 18(23):6694.
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Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription.
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