OPA1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of OPA1 in post-nuclear extracts of mouse embryonic fibroblasts with OPA1 polyclonal antibody (Cat # PAB12083).
Immunohistochemistry
Immunohistochemical staining of OPA1 on prostatic smooth muscle and glandular epithelium with OPA1 polyclonal antibody (Cat # PAB12083).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of OPA1.
Immunogen
A synthetic peptide corresponding to amino acids 500-600 of human OPA1.
Host
Rabbit
Reactivity
Chicken, Human, Mouse, Primates, Rat, Zebra fish
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (2 ug/mL)
Immunohistochemistry (2.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris-glycine, 150 mM NaCl (0.05% sodium azide)
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of OPA1 in post-nuclear extracts of mouse embryonic fibroblasts with OPA1 polyclonal antibody (Cat # PAB12083).Immunohistochemistry
Immunohistochemical staining of OPA1 on prostatic smooth muscle and glandular epithelium with OPA1 polyclonal antibody (Cat # PAB12083). -
Gene Info — OPA1
Entrez GeneID
4976Protein Accession#
O60313Gene Name
OPA1
Gene Alias
FLJ12460, KIAA0567, MGM1, NPG, NTG, largeG
Gene Description
optic atrophy 1 (autosomal dominant)
Gene Ontology
HyperlinkGene Summary
This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000195065|mitochondrial dynamin-like GTPase|optic atrophy 1
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Interactome
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Disease
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Publication Reference
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Lipids activate skeletal muscle mitochondrial fission and quality control networks to induce insulin resistance in humans.
Christopher L Axelrod, Ciaran E Fealy, Melissa L Erickson, Gangarao Davuluri, Hisashi Fujioka, Wagner S Dantas, Emily Huang, Kathryn Pergola, Jacob T Mey, William T King, Anny Mulya, Daniel Hsia, Bartolome Burguera, Bernard Tandler, Charles L Hoppel, John P Kirwan.
Metabolism: Clinical and Experimental 2021 Jun; 121:154803.
Application：WB-Ti, Human, Human skeletal muscle specimens.
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Exercise Training Remodels Human Skeletal Muscle Mitochondrial Fission and Fusion Machinery Towards a Pro-Elongation Phenotype.
Axelrod CL, Fealy CE, Mulya A, Kirwan JP.
Acta Physiologica 2018 Nov; e13216.
Application：WB-Ti, Human, Skeletal muscle.
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Effect of Roux-en-Y gastric bypass on liver mitochondrial dynamics in a rat model of obesity.
Sacks J, Mulya A, Fealy CE, Huang H, Mosinski JD, Pagadala MR, Shimizu H, Batayyah E, Schauer PR, Brethauer SA, Kirwan JP.
Physiological Reports 2018 Apr; 6:1.
Application：WB-Ce, Rat, Liver homogenates.
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Lipids activate skeletal muscle mitochondrial fission and quality control networks to induce insulin resistance in humans.
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