OPA1 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human OPA1 peptide using ARM Technology.
Immunogen
A synthetic peptide of human OPA1 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human OPA1 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — OPA1
Entrez GeneID
4976GeneBank Accession#
OPA1Gene Name
OPA1
Gene Alias
FLJ12460, KIAA0567, MGM1, NPG, NTG, largeG
Gene Description
optic atrophy 1 (autosomal dominant)
Gene Ontology
HyperlinkGene Summary
This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000195065|mitochondrial dynamin-like GTPase|optic atrophy 1
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Interactome
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Disease
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