APOB polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of APOB.
Immunogen
A synthetic peptide corresponding to human APOB.
Sequence
C-TDLHLRYQKDKK
Host
Goat
Theoretical MW (kDa)
516
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.3-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
APOB polyclonal antibody (Cat # PAB11488) (0.5 ug/mL) staining of human serum lysates. Data kindly provided by Yan Xie and NO Davidson, Washington USA. This antibody showed background below 150kDa in serum samples . We call for caution when used for other assays than Western blot.Enzyme-linked Immunoabsorbent Assay
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Gene Info — APOB
Entrez GeneID
338Protein Accession#
NP_000375.2Gene Name
APOB
Gene Alias
FLDB
Gene Description
apolipoprotein B (including Ag(x) antigen)
Gene Ontology
HyperlinkGene Summary
This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq
Other Designations
OTTHUMP00000115994|apoB-100|apoB-48|apolipoprotein B|apolipoprotein B48
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Interactome
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Disease
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Publication Reference
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Polymorphisms in apolipoprotein B and risk of ischemic stroke.
Benn M, Nordestgaard BG, Jensen JS, Tybjaerg-Hansen A.
The Journal of Clinical Endocrinology and Metabolism 2007 Sep; 92(9):3611.
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Polymorphisms in apolipoprotein B and risk of ischemic stroke.
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