ROBO1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot using ROBO1 polyclonal antibody (Cat # PAB10401) on human brain lysate. Lysate used at 15 ug/lane. Antibody used at 10 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ROBO1.
Immunogen
A synthetic peptide corresponding to human ROBO1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western blot (1 to 5 mg/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot using ROBO1 polyclonal antibody (Cat # PAB10401) on human brain lysate. Lysate used at 15 ug/lane. Antibody used at 10 ug/mL .Western Blot
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Gene Info — ROBO1
Entrez GeneID
6091Gene Name
ROBO1
Gene Alias
DUTT1, FLJ21882, MGC131599, MGC133277, SAX3
Gene Description
roundabout, axon guidance receptor, homolog 1 (Drosophila)
Omim ID
602430Gene Ontology
HyperlinkGene Summary
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
axon guidance receptor|roundabout 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Tumour specific promoter region methylation of the human homologue of the Drosophila Roundabout gene DUTT1 (ROBO1) in human cancers.
Dallol A, Forgacs E, Martinez A, Sekido Y, Walker R, Kishida T, Rabbitts P, Maher ER, Minna JD, Latif F.
Oncogene 2002 May; 21(19):3020.
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Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance.
Brose K, Bland KS, Wang KH, Arnott D, Henzel W, Goodman CS, Tessier-Lavigne M, Kidd T.
Cell 1999 Mar; 96(6):795.
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Tumour specific promoter region methylation of the human homologue of the Drosophila Roundabout gene DUTT1 (ROBO1) in human cancers.
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