IL17RA (Human) Recombinant Protein
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More Files
- More Functions
Enzyme-linked Immunoabsorbent Assay
Immobilized Human IL-17A, His Tag at 0.5 ug/mL (100 uL/well) on the plate. Dose response curve for Human IL-17R alpha, hFc Tag with the EC50 of 66.6 ng/mL determined by ELISA (QC Test).
Surface Plasmon Resonance
Human IL-17R alpha, hFc Tag captured on CM5 Chip via protein A can bind Biotinylated Human IL-17A, His-Avi Tag with an affinity constant of 2.18 nM as determined in SPR assay (Biacore T200).
SEC-HPLC
The purity of Human IL-17R alpha is greater than 95% as determined by SEC-HPLC.
Tris-Bis PAGE
Human IL-17R alpha on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
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Specification
Product Description
Human IL17RA (Q96F46-1, Leu33-Trp320) partial recombinant protein with hFc tag at C-Terminus expressed in HEK293 cells.
Sequence
Leu33-Trp320
Host
Human
Theoretical MW (kDa)
60.2
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Quality Control Testing
SEC-HPLC and Tris-Bis PAGE
SEC-HPLC
The purity of Human IL-17R alpha is greater than 95% as determined by SEC-HPLC.
Tris-Bis PAGE
Human IL-17R alpha on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Recommend Usage
Biological Activity
ELISA
SPR
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from sterile distilled Water is > 100 ug/mL
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
Result of bioactivity analysis
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Applications
Enzyme-linked Immunoabsorbent Assay
Immobilized Human IL-17A, His Tag at 0.5 ug/mL (100 uL/well) on the plate. Dose response curve for Human IL-17R alpha, hFc Tag with the EC50 of 66.6 ng/mL determined by ELISA (QC Test).Functional Study
SDS-PAGE
Surface Plasmon Resonance
Human IL-17R alpha, hFc Tag captured on CM5 Chip via protein A can bind Biotinylated Human IL-17A, His-Avi Tag with an affinity constant of 2.18 nM as determined in SPR assay (Biacore T200). -
Gene Info — IL17RA
Entrez GeneID
23765Protein Accession#
Q96F46-1Gene Name
IL17RA
Gene Alias
CD217, CDw217, IL-17RA, IL17R, MGC10262, hIL-17R
Gene Description
interleukin 17 receptor A
Omim ID
605461Gene Ontology
HyperlinkGene Summary
Interleukin 17A (IL17A)is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. [provided by RefSeq
Other Designations
interleukin 17A receptor
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Interactome
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Pathway
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Disease
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