TNFRSF11B (Human) Recombinant Protein
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Specification
Product Description
Human TNFRSF11B (O00300) recombinant protein expressed in Escherichia coli.
Sequence
METFPPKYLHYDEETSHQLLCDKCPPGTYLKQHCTAKWKTVCAPCPDHYYTDSWHTSDECLYCSPVCKELQYVKQECNRTHNRVCECKEGRYLEIEFCLKHRSCPPGFGVVQAGTPERNTVCKRCPDGFFSNETSSKAPCRKHTNCSVFGLLLTQKGNATHDNICSGNSESTQK.
Host
Escherichia coli
Theoretical MW (kDa)
20
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Purity
> 95% by HPLC and SDS PAGE
Activity
The activity is determined by the ability to neutralize the stimulation of U937 cells treated with 10 ng/mL of soluble RANKL corresponding to a specific activity of 100,000 IU/mg.
Storage Buffer
Lyophilized from PBS, pH 7.4.
Storage Instruction
Store at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles.
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Applications
Functional Study
SDS-PAGE
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Gene Info — TNFRSF11B
Entrez GeneID
4982Protein Accession#
O00300Gene Name
TNFRSF11B
Gene Alias
MGC29565, OCIF, OPG, TR1
Gene Description
tumor necrosis factor receptor superfamily, member 11b
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq
Other Designations
osteoclastogenesis inhibitory factor|osteoprotegerin
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Interactome
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Pathway
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Disease
- Acute Disease
- Alveolar Bone Loss
- Alzheimer disease
- Arthritis
- Asthma
- Body Weight
- Bone Diseases
- Brain Ischemia
- Calcinosis
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