TNFRSF11B (Human) Recombinant Protein
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Specification
Product Description
Human TNFRSF11B (O00300, 22 a.a. - 201 a.a.) partial-length recombinant protein and 232 residues from the Fc protein of human IgG1 expressed in Pichia pastoris.
Sequence
OPG22-201:ETFPPKYLHYDEETSHQLLCDKCPPGTYLKQHCTAKWKTVCAPCPDHYYTDSWHTSDECLYCSPVCKELQYVKQECNRTHNRVCECKEGRYLEIEFCLKHRSCPPGFGVVQAGTPERNTVCKRCPDGFFSNETSSKAPCRKHTNCSVFGLLLTQKGNATHDNICSGNSESTQKCGIDVTL|Fc232:EPKSSDKTHTCPPCPAPEFEGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPTPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
Host
Yeast
Theoretical MW (kDa)
109.6
Form
Lyophilized
Preparation Method
Pichia pastoris expression system
Purity
> 90% by HPLC and SDS PAGE
Activity
The ED50 as determined by neutralizing the stimulation of U937 cells is less tha10 ng/mL, corresponding to a specific activity of > 1.0 × 105 IU/mg in the presence of 10 ng/mL soluble Human RANKL (sRANKL).
Storage Buffer
Lyophilized from 20mM PB, pH 6.0, 150mM NaCl and 0.02 % Tween-80.
Storage Instruction
Store at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles.
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Applications
Functional Study
SDS-PAGE
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Gene Info — TNFRSF11B
Entrez GeneID
4982Protein Accession#
O00300Gene Name
TNFRSF11B
Gene Alias
MGC29565, OCIF, OPG, TR1
Gene Description
tumor necrosis factor receptor superfamily, member 11b
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq
Other Designations
osteoclastogenesis inhibitory factor|osteoprotegerin
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Interactome
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Pathway
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Disease
- Acute Disease
- Alveolar Bone Loss
- Alzheimer disease
- Arthritis
- Asthma
- Body Weight
- Bone Diseases
- Brain Ischemia
- Calcinosis
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