IL21 monoclonal antibody, clone SB134b
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant IL21.
Immunogen
Recombinant protein corresponding to full length human IL21.
Host
Mouse
Reactivity
Human
Specificity
This antibody is specific to IL21.
Form
Liquid
Isotype
IgG2b
Recommend Usage
ELISA (0.1-5 ug/mL)
Immunostaining (2-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In BBS, pH8.2
Storage Instruction
Store at 4°C.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — IL21
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Pathway
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Disease
- Addison Disease
- Alopecia Areata
- Arthritis
- Asthma
- Autoimmune Diseases
- Bronchiolitis
- Carcinoma
- Celiac Disease
- Colitis
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Publication Reference
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Interleukin-21: basic biology and implications for cancer and autoimmunity.
Spolski R, Leonard WJ.
Annual Review of Immunology 2008 Nov; 26:57.
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Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration.
Kuchen S, Robbins R, Sims GP, Sheng C, Phillips TM, Lipsky PE, Ettinger R.
Journal of Immunology 2007 Nov; 179(9):5886.
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IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells.
Ettinger R, Sims GP, Fairhurst AM, Robbins R, da Silva YS, Spolski R, Leonard WJ, Lipsky PE.
Journal of Immunology 2005 Dec; 175(12):7867.
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Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function.
Parrish-Novak J, Dillon SR, Nelson A, Hammond A, Sprecher C, Gross JA, Johnston J, Madden K, Xu W, West J, Schrader S, Burkhead S, Heipel M, Brandt C, Kuijper JL, Kramer J, Conklin D, Presnell SR, Berry J, Shiota F, Bort S, Hambly K, Mudri S, Clegg C, Moore M, Grant FJ, Lofton-Day C, Gilbert T, Rayond F, Ching A, Yao L, Smith D, Webster P, Whitmore T, Maurer M, Kaushansky K, Holly RD, Foster D.
Nature 2000 Nov; 408(6808):57.
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Interleukin-21: basic biology and implications for cancer and autoimmunity.
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