TNFRSF4 monoclonal antibody, clone Ber Act 35
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Specification
Product Description
Mouse monoclonal antibody raised against native TNFRSF4.
Immunogen
Native purified TNFRSF4 from human HUT 102 T cells.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In 50 mM sodium phosphate buffer, 100 mM potassium Chloride, 150 mM NaCl, pH 7.5 (0.5 mg/mL gentamicin sulfate)
Storage Instruction
Store at 4°C.
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Applications
Immunohistochemistry (Frozen sections)
Immunoprecipitation
Flow Cytometry
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Gene Info — TNFRSF4
Entrez GeneID
7293Gene Name
TNFRSF4
Gene Alias
ACT35, CD134, OX40, TXGP1L
Gene Description
tumor necrosis factor receptor superfamily, member 4
Omim ID
600315Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq
Other Designations
ATC35 antigen|CD134 antigen|OTTHUMP00000001522|OX40 antigen|OX40 cell surface antigen|OX40 homologue|lymphoid activation antigene ACT35|tax-transcriptionally activated glycoprotein 1 receptor
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Interactome
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Pathway
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Disease
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Publication Reference
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Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells.
Stuber E, Neurath M, Calderhead D, Fell HP, Strober W.
Immunity 1995 May; 2(5):507.
Application：Flow Cyt, Func, IP, Mouse, Mouse B cells.
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The human OX40 homolog: cDNA structure, expression and chromosomal assignment of the ACT35 antigen.
Latza U, Durkop H, Schnittger S, Ringeling J, Eitelbach F, Hummel M, Fonatsch C, Stein H.
European Journal of Immunology 1994 Mar; 24(3):677.
Application：Flow Cyt, WB-Tr, Human, Monkey, COS-1, HUT-102 cells.
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Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells.
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