TNFRSF4 monoclonal antibody, clone RM313
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More Files
- More Functions
Western Blot (Tissue lysate)
Western Blot (Tissue lysate) analysis of human spleen.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human tonsil.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human TNFRSF4.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to C-terminus of human TNFRSF4.
Reactivity
Human
Specificity
This antibody reacts to human TNFRSF4 (CD134).
Form
Liquid
Purification
Protein A purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200-500)
Western Blot (1:1000-2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol, 1% BSA, 0.09% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western Blot (Tissue lysate) analysis of human spleen.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human tonsil. -
Gene Info — TNFRSF4
Entrez GeneID
7293Gene Name
TNFRSF4
Gene Alias
ACT35, CD134, OX40, TXGP1L
Gene Description
tumor necrosis factor receptor superfamily, member 4
Omim ID
600315Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq
Other Designations
ATC35 antigen|CD134 antigen|OTTHUMP00000001522|OX40 antigen|OX40 cell surface antigen|OX40 homologue|lymphoid activation antigene ACT35|tax-transcriptionally activated glycoprotein 1 receptor
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Interactome
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Pathway
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Disease
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