SLC3A2 monoclonal antibody, clone MEM-108 (FITC)
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Specification
Product Description
Mouse monoclonal antibody raised against native SLC3A2.
Immunogen
Native purified SLC3A2 from Raji Burkitt's lymphoma cell line.
Host
Mouse
Theoretical MW (kDa)
125
Reactivity
Human
Specificity
This antibody reacts with CD98, a 125 KDa disulfide-linked heterodimer (80 KDa glycosylated heavy chain + 45 KDa non-glykosylated light chain).
Form
Liquid
Conjugation
FITC
Isotype
IgG1
Recommend Usage
Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
urface staining of human peripheral blood cells with SLC3A2 monoclonal antibody, clone MEM-108 (FITC) (Cat # MAB5041). Cells in the monocyte gate were used for analysis. -
Gene Info — SLC3A2
Entrez GeneID
6520Gene Name
SLC3A2
Gene Alias
4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE
Gene Description
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
Omim ID
158070Gene Ontology
HyperlinkGene Summary
This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein with an alpha amylase domain. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. It associates with integrins and mediates integrin-dependent signaling related to normal cell growth and tumorigenesis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Other Designations
4F2 cell-surface antigen heavy chain|4F2 heavy chain|CD98 heavy chain|antigen defined by monoclonal antibody 4F2, heavy chain|antigen identified by monoclonal antibodies 4F2, TRA1.10, TROP4, and T43|heavy chain|lymphocyte activation antigen 4F2 large subu
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Interactome
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Disease
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Publication Reference
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Differential effect of cross-linking the CD98 heavy chain on fusion and amino acid transport in the human placental trophoblast (BeWo) cell line.
Dalton P, Christian HC, Redman CW, Sargent IL, Boyd CA.
Biochimica et Biophysica Acta 2007 Mar; 1768(3):401.
Application:Flow Cyt, IEM, Human, Human placental trophoblast (BeWo) cell line.
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CD98 modulates integrin beta1 function in polarized epithelial cells.
Cai S, Bulus N, Fonseca-Siesser PM, Chen D, Hanks SK, Pozzi A, Zent R.
Journal of Cell Science 2005 Mar; 118(Pt 5):889.
Application:Flow Cyt, Mouse, Immortalized mouse inner medullary collecting duct (IMCD) cells.
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CD98-dependent homotypic aggregation is associated with translocation of protein kinase Cdelta and activation of mitogen-activated protein kinases.
Cho JY, Skubitz KM, Katz DR, Chain BM.
Experimental Cell Research 2003 May; 286(1):1.
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Differential effect of cross-linking the CD98 heavy chain on fusion and amino acid transport in the human placental trophoblast (BeWo) cell line.
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