CD97 monoclonal antibody, clone MEM-180 (FITC)
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Specification
Product Description
Mouse monoclonal antibody raised against native CD97.
Immunogen
Native purified CD97 from PHA-activated peripheral blood cells.
Host
Mouse
Theoretical MW (kDa)
75-85
Reactivity
Human
Specificity
This antibody recognizes an unique epitope on CD97, a 75-85 KDa surface glycoprotein of G-protein-coupled receptor family, expressed on activated B and T lymphocytes, monocytes/macrophages, dendritic cells and granulocytes.
Form
Liquid
Conjugation
FITC
Isotype
IgG1
Recommend Usage
Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
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Gene Info — CD97
Entrez GeneID
976Gene Name
CD97
Gene Alias
TM7LN1
Gene Description
CD97 molecule
Omim ID
601211Gene Ontology
HyperlinkGene Summary
This gene is a member of the EGF-TM7 family of class II seven-span transmembrane (7-TM) molecules, likely encoded by a gene cluster on the short arm of chromosome 19. The encoded product is a glycoprotein that is present on the surface of most activated leukocytes and spans the membrane seven times, which is a defining feature of G protein-coupled receptors. The protein has an extended extracellular region with several N-terminal epidermal growth factor (EGF)-like domains, which mediate binding to its cellular ligand, decay accelerating factor (DAF, CD55), a regulatory protein of the complement cascade. The presence of structural features characteristic of extracellular matrix proteins and transmembrane proteins suggests that this protein is a receptor involved in both cell adhesion and signaling processes early after leukocyte activation. Alternative splicing has been observed for this gene and three variants have been found. [provided by RefSeq
Other Designations
CD97 antigen|leukocyte antigen CD97|seven transmembrane helix receptor|seven-span transmembrane protein|seven-transmembrane, heterodimeric receptor associated with inflammation
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Interactome
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Disease
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Publication Reference
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Structural and functional characterization of a novel T cell receptor co-regulatory protein complex, CD97-CD55.
Abbott RJ, Spendlove I, Roversi P, Fitzgibbon H, Knott V, Teriete P, McDonnell JM, Handford PA, Lea SM.
The Journal of Biological Chemistry 2007 Jul; 282(30):22023.
Application：Flow Cyt, Func, Human, PBMCs.
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Improved antibacterial host defense and altered peripheral granulocyte homeostasis in mice lacking the adhesion class G protein receptor CD97.
Wang T, Tian L, Haino M, Gao JL, Lake R, Ward Y, Wang H, Siebenlist U, Murphy PM, Kelly K.
Infection and Immunity 2007 Mar; 75(3):1144.
Application：Flow Cyt, Mouse, Mouse bone marrow granulocytes, splenic B and T cells.
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Individual cell-based models of tumor-environment interactions: Multiple effects of CD97 on tumor invasion.
Galle J, Sittig D, Hanisch I, Wobus M, Wandel E, Loeffler M, Aust G.
The American Journal of Pathology 2006 Nov; 169(5):1802.
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Structural and functional characterization of a novel T cell receptor co-regulatory protein complex, CD97-CD55.
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