ZAP70 monoclonal antibody, clone SBZAP
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant ZAP70.
Immunogen
Recombinant protein corresponding to amino acids 280-309 of human ZAP70.
Host
Mouse
Reactivity
Human
Specificity
human ZAP-70.
Form
Liquid
Isotype
IgG1
Recommend Usage
Flow Cytometry (1 ug/106cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In 100 mM BBS, pH 8.2
Storage Instruction
Store at 4°C.
-
Applications
Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
-
Gene Info — ZAP70
Entrez GeneID
7535Gene Name
ZAP70
Gene Alias
FLJ17670, FLJ17679, SRK, STD, TZK, ZAP-70
Gene Description
zeta-chain (TCR) associated protein kinase 70kDa
Omim ID
176947Gene Ontology
HyperlinkGene Summary
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq
Other Designations
syk-related tyrosine kinase|zeta-chain (TCR) associated protein kinase (70 kD)|zeta-chain associated protein kinase 70kDa|zeta-chain associated protein kinase, 70kD
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
The Syk/ZAP-70 protein tyrosine kinase connection to antigen receptor signalling processes.
van Oers NS, Weiss A.
Seminars in Immunology 1995 Aug; 7(4):227.
-
F2(Pmp)2-TAM zeta 3, a novel competitive inhibitor of the binding of ZAP-70 to the T cell antigen receptor, blocks early T cell signaling.
Wange RL, Isakov N, Burke TR Jr, Otaka A, Roller PP, Watts JD, Aebersold R, Samelson LE.
The Journal of Biological Chemistry 1995 Jan; 270(2):944.
Application：WB-Ce, Human, Jurkat cells.
-
The Syk/ZAP-70 protein tyrosine kinase connection to antigen receptor signalling processes.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com