TIMP1 monoclonal antibody, clone 2A5
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of TIMP1.
Immunogen
A synthetic peptide corresponding to human TIMP1.
Host
Mouse
Reactivity
Human, Monkey
Form
Liquid
Isotype
IgG1
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western blot analysis of TIMP1 expression in TIMP1 monoclonal antibody, clone 2A5 (Cat # MAB1799) against recombinant human TIMP1 proenzyme (400 ng lane).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of TIMP1 on human colon carcinoma tissue with TIMP1 monoclonal antibody, clone 2A5 (Cat # MAB1799).Enzyme-linked Immunoabsorbent Assay
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Gene Info — TIMP1
Entrez GeneID
7076Gene Name
TIMP1
Gene Alias
CLGI, EPA, EPO, FLJ90373, HCI, TIMP
Gene Description
TIMP metallopeptidase inhibitor 1
Omim ID
305370Gene Ontology
HyperlinkGene Summary
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq
Other Designations
OTTHUMP00000023214|erythroid potentiating activity|fibroblast collagenase inhibitor|tissue inhibitor of metalloproteinase 1
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Interactome
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Disease
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Publication Reference
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Tissue MMP-2 and MMP-9 [corrected] are better prognostic factors than serum MMP-2/TIMP-2--complex or TIMP-1 [corrected] in stage [corrected] I-III lung carcinoma.
Hoikkala S, Pääkkö P, Soini Y, Mäkitaro R, Kinnula V, Turpeenniemi-Hujanen T.
Cancer Letters 2006 May; 236(1):125.
Application:ELISA, IHC-P, Human, Human lung cancer.
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Functional domains of human TIMP-1 (tissue inhibitor of metalloproteinases).
Bodden MK, Harber GJ, Birkedal-Hansen B, Windsor LJ, Caterina NC, Engler JA, Birkedal-Hansen H.
The Journal of Biological Chemistry 1994 Jul; 269(29):18943.
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Tissue MMP-2 and MMP-9 [corrected] are better prognostic factors than serum MMP-2/TIMP-2--complex or TIMP-1 [corrected] in stage [corrected] I-III lung carcinoma.
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