TIMP1 monoclonal antibody (M01), clone 4D12
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant TIMP1.
Immunogen
TIMP1 (AAH07097, 1 a.a. ~ 169 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MAPFEPLASGILLLLWLIAPSRACTCVPPHPQTAFCNSDLVIRAKFVGTPEVNQTTLYQRYEIKMTKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLIAGKLQDGLLHITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCL
Host
Mouse
Reactivity
Human
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of TIMP1 expression in transfected 293T cell line by TIMP1 monoclonal antibody (M01), clone 4D12.
Lane 1: TIMP1 transfected lysate(23.2 KDa).
Lane 2: Non-transfected lysate.
Immunoprecipitation
Immunoprecipitation of TIMP1 transfected lysate using anti-TIMP1 monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with TIMP1 MaxPab rabbit polyclonal antibody.Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged TIMP1 is approximately 3ng/ml as a capture antibody.ELISA
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Gene Info — TIMP1
Entrez GeneID
7076GeneBank Accession#
BC007097Protein Accession#
AAH07097Gene Name
TIMP1
Gene Alias
CLGI, EPA, EPO, FLJ90373, HCI, TIMP
Gene Description
TIMP metallopeptidase inhibitor 1
Omim ID
305370Gene Ontology
HyperlinkGene Summary
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq
Other Designations
OTTHUMP00000023214|erythroid potentiating activity|fibroblast collagenase inhibitor|tissue inhibitor of metalloproteinase 1
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Interactome
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