FBXL10 monoclonal antibody (M09), clone 5G1
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More Files
- More Functions
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged FBXL10 is approximately 0.1ng/ml as a capture antibody.
Immunofluorescence
Immunofluorescence of monoclonal antibody to FBXL10 on HeLa cell. [antibody concentration 10 ug/ml]
Western Blot detection against Immunogen (36.63 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant FBXL10.
Immunogen
FBXL10 (NP_115979, 457 a.a. ~ 555 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
LGKKPKAPALRFLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEH
Host
Mouse
Interspecies Antigen Sequence
Mouse (93); Rat (95)
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.63 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged FBXL10 is approximately 0.1ng/ml as a capture antibody.ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to FBXL10 on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — FBXL10
Entrez GeneID
84678GeneBank Accession#
NM_032590Protein Accession#
NP_115979Gene Name
FBXL10
Gene Alias
CXXC2, Fbl10, JHDM1B, KDM2B, PCCX2
Gene Description
F-box and leucine-rich repeat protein 10
Omim ID
609078Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq
Other Designations
JEMMA (Jumonji domain, EMSY-interactor, methyltransferase motif) protein|jumonji C domain-containing histone demethylase 1B|protein containing CXXC domain 2
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Interactome
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Disease
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Publication Reference
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JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes.
Frescas D, Guardavaccaro D, Bassermann F, Koyama-Nasu R, Pagano M.
Nature 2007 Nov; 450(7167):309.
Application：IF, Human, HeLa cells.
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JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes.
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